CHO and HEK stable
cell line development

Host system CHOExpress®, outstanding technologies for fast generation of high-yield cell lines, and scalable manufacturing processes are the result of more than 20 years of deeply committed research, innovation, and optimisation.

Any Protein Format

mAbs, bispecifics, fusion proteins,
biosimilars, virus suface proteins, etc.

Speedy timeline

From DNA to stable, high-yield clone in 8 weeks

Robust cells for scalable processes

Scalability to over 5’000 L without loss of productivity

High Titers

Up to 14 g/L, fully chemically defined process

Unmatched Clone Stability

Over 95% of our clones are stable

From DNA to IND

Your gene is integrated into transcriptionally active DNA, guaranteeing high productivity, high cell line stability (>95%), and high comparability between stable pools and clonally derived cell lines.

  • Extensive media and feed screening to identify optimal production conditions
  • Cell line stability study is included
  • Development of scalable upstream and downstream processes and tech transfer (optional)
  • Use of Design of Experiments (DoE) for process optimization
  • State-of-the-art FDA and EMA compliant cloning procedures for documented proof of clonality
  • Support for assay development and analytics
  • Cell line development reports that support clinical trials and market authorization (IND, CTA/BLA, MAA)
  • Full freedom in the choice of media and feeds, including proprietary media
  • Licensing opportunities for the CLD platform are available.