OUR OFFERINGS

Expect great science.
It’s in our DNA.

ExcellGene’s reliable process and exceptional CHO cell hosts are the result of over twenty years of innovation and fine-tuning.

OUR SERVICES

A uniquely
science-driven CDMO

Since 2001, ExcellGene has developed proprietary technologies and know-how that are key for the delivery of its clients’ projects on a timely manner and with a high degree of customization.

CHO and HEK stable cell line development

Bioprocess Development

High Throughput Protein Production

Tox Material

cGMP Cell Bank Manufacturing

OUR TECHNOLOGIES

Out licensing of
superior cell hosts

In-house state-of-the-art tech
revolutionizing your development programs.

CHOExpress®
hosts cells

The fastest growing CHO host for biotech

We developed a uniquely high-performing  production host system for large-scale manufacturing. CHOExpress® derivative clonal populations commonly show fast growth to densities over 20 million cells/mL, process yields over 5 g/L, and great robustness for high-scale manufacturing (1oo doublings).

The cell line is the result of nearly a decade of work, and is validated with FDA and EMEA cell line documentation, including TSE, BSE and mycoplasma-free statements. The cell line is immortalized.

CHOExpress® is highly compatible with other systems, and can be used royalty-free. ExcellGene will guide you in ensuring favorable phenotypes in CHOExpress®-derived clonal populations. Our knowledge on gene transfer and isolation of top-performing cell populations is at your disposal.

FlexiCHO® medium.

A high performance chemically defined medium formulation for growth and production and for biosimilar quality adjustements.

HEKExpress®
hosts cells

Pioneering single-cell suspension for transient gene expression and virus like particle production

HEKExpress® is a fast-growing, productive and robust HEK-293 derived cell line for large-scale manufacturing of recombinant proteins.

After nearly a decade of work with the adherent cell line, ExcellGene has generated an aggregate-free single-cell suspension culture with very high transfection efficiency. This also means scale-up in serum-free, animal component-free or chemically defined media is easy.

HEKExpress® demonstrates the highest TGE yield ever reported in the literature (> 1g/L). HEK-293 cells are commonly used for academic research, and are very suited for transient gene expression. The host system can be licensed along with our proprietary chemically defined medium.

Features

  • A single-cell suspension host system for TGE and VLP production
  • Highest transient expression yield ever reported in the literature (> 1g/L)
  • Highly efficient in AAV9 production and lentivirus. Baculovirus-free
  • Fully characterized, ready for cGMP master cell bank generation and cGMP production
  • Single-cell suspension – no aggregates!
  • Easy scale-up in various animal component free media types
  • High cell density culture in ExcellGene’s CD media and feeds.

HEKzeroT® host cells

A clonally derived, T-antigen-free host cell system with superior AAV-VLP production capacity.

FlexiHEK® medium.

A high performance chemically defined medium formulation for growth and production for recombinant proteins.

BIOSIMILARS

Dynamic Portfolio of
high-producing Biosimilars,
Off-the-Shelf and
Tailored On-Demand.

Cost and time-savings, while bringing your product to the market.

Off-the-Shelf Biosimilars:

Choose from our range of high-producing clonal Research Cell Banks (RCBs), ­providing the option to seamlessly integrate affiliated Upstream (USP) ­and Downstream (DSP) processes and respective analytics, all available for immediate transfer.

Tailored On-Demand Biosimilar Services :

Adapted to your specific needs, we ­deliver high-producing biosimilar clones ­developed from DNA to research cell bankswithin 2 months. Benefit from our complete USP, DSP and analytical capabilities, along with characterized Master Cell Banks (MCB), provided in less than a year.
Furthermore, we offer biosimilarity optimisation for your existing cell line, customized to your targeted market.