Genome Engineering & Inducible Expression

Customized host cells tailored to the needs of your molecule
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An increasing diversity of molecular designs and protein targets often prove to be challenging for expression and production in naive host systems. A variety of different issues can hinder the production of your target protein; inadequate protein folding, inappropriate protein quality attributes, low expression levels, or cytotoxic effects of the protein on the production cells.

Typically considered as “problematic” molecules can belong to one of following groups:​ Different protein proteases/ enzymes, cytokines, hormones, adhesion molecules, large multimeric proteins and more.

To increase volumetric productivity (e.g. by elevating toxic effects of the protein)

 


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To obtain a specific protein quality (e.g. desired glycoprofile, prevent product cleavage)

To satisfy
some regulatory
requirements
(e.g. T antigen-negative HEK 293 cells)

 


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HOW WE CAN HELP

Application of knock-out and/or knock-in strategies designed for specific challenge

  • Using CRISPR/Cas9 technology
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  • Or CRISPR-like technology
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  • Or application of inducible systems for protein expression