Stabilized Alpha Trimeric Spike ProteinProduced in CHO cells. Available in mg to grams.
The Alpha variant, also known as B.1.1.7., was emerging as a VOCs after a mutation in the spike protein D614G, was recognized as possibly affecting the infectivity in people in an enhanced way. The Alpha variant carried this mutation and others, for example, N501Y, and was considered 40-80% more transmissible than the original “Wuhan” strain.
This product is intended for research use only.
|Stabilized Alpha Trimeric Spike Protein|
|Sequence modifications||C-terminal Transmembrane region replaced with a trimerization domain and a polyhistidine tag. Two stabilizing proline mutations. Scrambled S1/S2 furin cleavage site. D614G amino acid change.|
|Isolate (Seq ID)||–|
|Expression system||CHOExpress® cells|
|Purity||> 95 % as determined by SDS-PAGE.|
|Buffer||0.01M PBS, pH 7.4, no preservatives|
|Availability||mg to grams|